Fig. 6 | Scientific Reports

Fig. 6

From: Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing

Fig. 6

Assessment and validation of the prognostic Model. (A) Training set divided into high- and low-risk groups based on the median risk score. (B) Distribution of survival and death for patients in the training set with different risk scores. (C) Kaplan–Meier survival curve in the training set showing a poorer prognosis for patients in the high-risk group (P = 3.373e−05). (D) TimeROC analysis results for the training set at 1 (AUC = 0.715), 2 (AUC = 0.691), and 3 (AUC = 0.691) years. (E) Risk scores in terms of age, sex, and pathologic status obtained via multivariate COX regression analysis. Our model had an independent prognostic power (HR = 4.485; 95% CI [2.858, 7.040], P < 0.001). (F) Kaplan–Meier survival curve for the validation set showing a worse prognosis for the high-risk group (P = 2.612e−02) than for the low-risk group. (G) TimeROC analysis results for the validation set at 1 (AUC = 0.731), 2 (AUC = 0.792), and 3 (AUC = 0.726) years. ROC receiver operating characteristic, AUC area under the curve, HR hazard ratio, CI confidence interval. P < 0.05 is statistically significant.

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