Fig. 5
(A) Quantitative analysis of tumor-to-normal tissue ratios (T/NT ratios) was performed to compare the uptake of 68Ga-SC691 and 68Ga-PSMA-11 in primary PCa lesions relative to selected normal organs (salivary glands, liver, and kidneys). Mean T/NT ratios with standard deviations are presented as bar graphs. The results indicated that 68Ga-SC691 showed relatively better accumulation in primary PCa lesions, as well as in bone and lymph node metastases, coupled with significantly lower liver uptake compared to 68Ga-PSMA-11 (P < 0.05). (B) Quantitative analysis of tumor-to-background ratios (TBRs) was conducted to compare 68Ga-SC691 and 68Ga-PSMA-11 uptake in primary PCa lesions, bone metastases, and lymph node metastases. Data are presented as bar graphs showing mean TBRs with standard deviations as error bars. While 68Ga-SC691 demonstrated slightly lower TBR values than 68Ga-PSMA-11 in all lesion types (primary lesions, bone metastases, and lymph node metastases), the TBRs for both radiotracers remained above 25, indicating excellent tumor-to-background contrast.
