Table 4 Analysis of the high-risk nsSNPs in TLR3’s evolutionary conservation profile using the NetSurfP 2.0 database.

From: “In silico analysis of human TLR3 missense single nucleotide polymorphisms and their potential association with cancer”

Mutations

Class Assignment

Secondary Structure

RSA (%)

ASA (A²)

N284I

Buried

Coil

3

4

C37R

Buried

Coil

2

3

Q538P

Buried

Coil

11

20

L360P

Buried

Strand

2

4

  1. RSA: relative surface accessibility [¼ ASA/Max ASA].
  2. ASA: absolute surface accessibility.
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