Table 1 Composition and physicochemical characteristics of liquid SNEDDS (mean ± SD, n = 3).
F1 | F2 | |
|---|---|---|
A.Composition (% w/w) | ||
Oleic acid | 24.84 | 24.84 |
Atorvastatin | 0.621 | 0.621 |
Tween 80 | 24.84 | 24.84 |
Span 80 | 59.63 | 59.63 |
Chitosan | ------ | 1.00 |
B.Physicochemical Properties | ||
Size (nm) | 36.68 ± 3.21 | 272.7 ± 6.18 |
PDI | 0.251 ± 0.01 | 0.40 ± 0.04 |
Zeta potential (mV) | -29.22 ± 0.65 | -4.55 ± 2.57 |
Viscosity (mPa.s) | 16.29 ± 1.05 | 22.12 ± 1.48 |
Surface tension (Dyne/cm) | 0.069 ± 0.005 | 0.056 ± 0.003 |
Density (g/cm3) | 1.125 ± 0.111 | 1.243 ± 0.052 |
pH | 5.62 ± 0.57 | 4.54 ± 0.71 |
Drug content (mg/ml) | 5.86 ± 0.08 | 5.91 ± 0.03 |
Drug release | Initial higher burst drug release followed by sustained release following Fickian diffusion | Lower burst drug release followed by comparatively sustained drug release Fickian diffusion |
