Fig. 1 | Scientific Reports

Fig. 1

From: Sd-021, derivatives of decursin, inhibits tumorigenesis in NSCLC by inhibiting the EGFR/STAT3 signaling pathway

Fig. 1

Comparison of the effects of decursin and Sd-021 on inhibiting viability in NSCLC cell lines. (A) Results from the MTT assay after treating A549, H460, H1299, and HCC827 cells with decursin or Sd-021 in a concentration-dependent manner (3.125, 6.25, 12.5, 25, and 50 µM) and time-dependent manner (24, 48, and 72 h). The data are expressed as mean ± standard deviation. Statistical analysis was performed using unpaired t-tests. *Indicates comparison with 0 µM; # indicates comparison with decursin at the same concentration. Significance levels: p < 0.05 ( * or #), p < 0.01 (** or ##), p < 0.001 (*** or ###). (B) Outcomes from the clonogenic assay displaying colony formation after treatment of A549, H460, H1299, and HCC827 cells with decursin or Sd-021 at varying concentrations (0.625, 1.25, 2.5, 5, and 10 µM).

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