Table 10 PPIX whole blood stability results.

From: Protoporphyrin IX plasma and blood pharmacokinetics and brain tumor distribution determined by a validated LC–MS/MS method

Matrix

Stability

Bench Top

Freeze–Thaw

Autosampler

Processed Sample

Long-term

QC Level

LQC

HQC

LQC

HQC

LQC

HQC

LQC

HQC

LQC

HQC

Nominal Conc. (nM)

30.0

1530

30.0

1530

30.0

1530

30.0

1530

30.0

1530

Blood

Period

5 h

2 cycles

72 h

5 h

71 days

Mean Conc. (nM)

31.3

1560

31.8

1610

32.8

1600

31.5

1510

28.4

1430

Accuracy (%)

104.3

102.0

106.0

105.2

109.3

104.6

105.0

98.7

94.7

93.5

CV (%)

2.1

2.3

1.1

3.4

0.6

1.3

4.5

1.4

2.5

2.8

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