Table 2 Genetic validation of selected phenotypes, and the number of cases and controls included in the UK Biobank analysis and in the reference studies.

Phenotype	Published study	r_g	SE	P value	UK biobank		Published study
Phenotype	Published study	r_g	SE	P value	# Cases	# Control	# Cases	# Controls
Diabetes, type 2	Scott et al.⁴⁵	0.97	0.03	5.15E−231	37,189	421,251	26,676	132,532
Psoriasis	Tsoi et al.⁴⁶	0.83	0.05	5.14E−63	14,844	443,596	10,588	22,806
Ulcerative colitis	de Lange et al.⁴⁷	0.94	0.07	2.04E−40	6094	452,346	12,366	33,609
Rheumatoid arthritis	Okada et al.⁴⁸	0.76	0.07	1.32E−30	11,961	446,479	14,361	43,923
Peripheral arterial disease	Klarin et al.⁴⁹	1.03	0.09	1.66E−30	8984	449,456	24,009	150,983
Crohn’s disease	de Lange et al.⁴⁷	0.95	0.08	1.84E−30	2992	455,448	12,194	28,072
Osteoarthritis	arcOGEN (2012)	0.65	0.06	2.13E−25	119,948	338,492	14,883	53,947
Schizophrenia	Lam et al.⁵⁰	0.96	0.11	1.88E−17	2165	456,275	33,640	43,456
Bipolar affective disorder	Stahl et al.⁵¹	0.84	0.17	9.99E−07	3692	454,748	3421	22,155
Primary malignancy, ovarian	Phelan et al.⁵²	0.77	0.73	2.93E−01	2375	246,224	29,396	68,502

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