Table 3 Clinical characteristics of PH infants with and without PS administration.

From: Inhaled nitric oxide as an independent intervention to lower the risk of bronchopulmonary dysplasia in preterm infants (< 33 weeks) with pulmonary hypertension within the initial 3 days of life

Variable

Surfactant (n = 30)

N-Surfactant(n = 26)

P-value

Age, (mean ± SD weeks)

28.4 ± 2.4

28.8 ± 1.8

0.66

Gender (male/female)

11/19

19/7

0.006

Weight, (mean ± SD g))

1104 ± 359

1168 ± 284

0.34

Apgar 1 min, (median, quartile)

6 (4,7.25)

7.5 (5,9)

0.09

Apgar 5 min, (median, quartile)

8 (7,9)

9 (8,9.5)

0.09

Before treatment P/F ratio, (mean ± SD)

121.7 ± 47.8

139.4 ± 71.2

0.42

24 h After treatment P/F ratio, (mean ± SD)

256.3 ± 104.2

288.9 ± 77.9

0.21

ABG PH 1 h after birth, (mean ± SD)

7.237 ± 0.083

7.017 ± 0.125

0.19

Cesarean, n (%)

21 (70.0)

26 (53.8)

0.21

Twin, n (%)

13 (43.3)

5 (19.2)

0.10

SGA, n (%)

4 (13.3)

2 (7.7)

0.81

PROM, n (%)

5 (16.7)

6 (23.1)

0.55

GDM, n (%)

0

0

–

Abortion history, n (%)

14 (46.7)

8 (36.4)

0.22

Gestational infection, n (%)

8 (26.7)

3 (11.5)

0.28

PIH, n (%)

6 (20.0)

2 (25.0)

0.35

RDS, n (%)

23 (76.7)

8 (30.8)

0.001

EOS, n (%)

16 (53.3)

14 (53.8)

0.97

NEC, n (%)

2 (6.7)

2 (7.7)

0.71

PDA, n (%)

17 (56.7)

9 (34.6)

0.09

Pneumothorax, n (%)

4 (13.3)

1 (3.8)

0.44

MAS, n (%)

2 (6.7)

1 (3.8)

0.89

Milrinone, n (%)

13 (43.3)

9 (34.6)

0.51

iNO, n (%)

14 (46.7)

6 (23.1)

0.07

Vasoconstrictive drug, n (%)

12 (40.0)

13 (50.0)

0.45

Mechanical ventilation, n (%)

27 (90.0)

21 (80.8)

0.33

Sildenafil, n (%)

12 (40.0)

17 (64.4)

0.06

BPD, n (%)

9 (30.0)

17 (65.4)

0.008

ROP, n (%)

7 (23.3)

4 (15.4)

0.68

IVH, n (%)

9 (30.0)

4 (15.4)

0.33

Death, n (%)

0

0

–

  1. PS = Pulmonary surfactant; BPD = Bronchopulmonary Dysplasia; ROP = Retinopathy of Prematurity; P/F ratio =, Partial Pressure of Oxygen (PaO₂)/ Fraction of Inspired Oxygen( FiO₂ ); PH = Pulmonary Hypertension; RDS = Respiratory Distress Syndrome; NEC = Necrotizing Enterocolitis; IVH = Intraventricular Hemorrhage; EOS = Early-Onset Sepsis; SGA = Small for Gestational Age; PROM = Premature Rupture of Membranes; GDM = Gestational Diabetes Mellitus; PIH = Pregnancy-Induced Hypertension; MAS = Meconium Aspiration Syndrome; iNO = Inhaled nitric oxide.
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