Table 3 Association between ALT/HDL-C and risk of hepatic fibrosis.

From: Utility of the serum alanine aminotransferase to high density lipoprotein cholesterol ratio in evaluating nonalcoholic fatty liver disease and liver fibrosis

Degree of hepatic fibrosis

Model 1

OR (95% CI), P value

Model 2

OR (95% CI), P value

Model 3

OR (95% CI), P value

Significant fibrosis

(F2, LSM ≥ 8.0 kPa)

2.414 (1.997, 2.918)

< 0.001

2.825 (2.309, 3.457)

< 0.001

2.274 (1.848, 2.797)

< 0.001

Men

1.788 (1.438, 2.225)

< 0.001

2.112 (1.670, 2.670) < 0.001

1.915 (1.485, 2.468)

< 0.001

Women

5.446 (3.698, 8.022)

< 0.001

6.438 (4.257, 9.736)

< 0.001

3.785 (2.478, 5.782)

< 0.001

Advanced fibrosis

(F3, LSM ≥ 9.7 kPa)

2.293 (1.876, 2.803) < 0.001

2.684 (2.163, 3.329) < 0.001

2.200 (1.763, 2.746)

< 0.001

Men

1.806 (1.420, 2.296) < 0.001

2.163 (1.664, 2.811)

< 0.001

1.983 (1.493, 2.633)

< 0.001

Women

4.182 (2.783, 6.284)

< 0.001

4.767 (3.088, 7.359)

< 0.001

2.919 (1.952, 4.364)

< 0.001

Cirrhosis

(F4, LSM ≥ 13.7 kPa)

1.959 (1.546, 2.482)

< 0.001

2.205 (1.715, 2.835) < 0.001

1.870 (1.447, 2.418)

< 0.001

Men

1.449 (1.118, 1.879)

0.005

1.655 (1.237, 2.216)

< 0.001

1.604 (1.220, 2.108)

< 0.001

Women

3.693 (2.367, 5.762)

< 0.001

4.023 (2.511, 6.446)

< 0.001

2.832 (1.891, 4.241)

< 0.001

  1. Model 1: no covariates were adjusted. Model 2: age, gender, and race were adjusted. Model 3: age, gender, race, hypertension, BMI, T2DM, smoke, physical activity level, CAP, fast glucose, fast insulin, HbA1c, TBIL, ALP, GGT, AST, TG, CRP, and SUA were adjusted. In the subgroup analysis for gender, the model was not adjusted for gender.
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