Fig. 4

AGGF1-primed EPCs implantation suppresses oxidative damage, fibrosis and inflammation in diabetic I/R mice. (A) MDA content analysis of myocardial tissue. (B) SOD content assay of myocardial tissue. (C) Masson staining (Scale bar = 1000 μm), Sirius Red staining (Scale bar = 1000 μm) and immunohistochemistry assay (Scale bar = 50 μm) of cardiac sections from diabetic I/R mice. (D) Quantification of Masson staining and Sirius Red staining. (E) Representative images of mice hearts from sham controls, I/R mice, I/R + EPCs mice, and I/R + AGGF1-EPCs mice with immunohistochemical analysis of LY6G, MCP1, TNF-α, IL-1β, and IL-6. (F) Quantification data on inflammation markers LY6G, MCP1, TNF-α, IL-1β, and IL-6. Data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 6.