Fig. 4 | Scientific Reports

Fig. 4

From: Effect of defective H2B ubiquitination on the malignancy and repair of DNA double breaks and its significance in lung adenocarcinoma

Fig. 4

RNF20 Knockdown Promotes Tumor Growth in a Chinese Hamster Buccal Mucosa Model. (a) Immunofluorescence staining of tumor sections for CK8 (red) and MAGE-A (green). Magnification: 40×, scale bar: 500 μm. Right panel: Magnified view of the boxed region. (b) Representative hematoxylin and eosin (H&E)-stained sections of xenograft tumors are shown. Low-magnification (Magnification: 4×, scale bar: 200 μm) and high-magnification (Magnification: 10×, scale bar: 50 μm) views demonstrate tumor cell morphology, with red arrowheads indicating regions of atypical mitotic figures and nuclear pleomorphism. (c) Representative image of tumor growth on day 3 after injection of A549 cells into the buccal mucosa. Tumor volume measured on day 3. (d)Tumors derived from RNF20-silenced cells were significantly larger, scale: mm. (*P < 0.05)

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