Fig. 4 | Scientific Reports

Fig. 4

From: Effect of defective H2B ubiquitination on the malignancy and repair of DNA double breaks and its significance in lung adenocarcinoma

Fig. 4The alternative text for this image may have been generated using AI.

RNF20 Knockdown Promotes Tumor Growth in a Chinese Hamster Buccal Mucosa Model. (a) Immunofluorescence staining of tumor sections for CK8 (red) and MAGE-A (green). Magnification: 40×, scale bar: 500 μm. Right panel: Magnified view of the boxed region. (b) Representative hematoxylin and eosin (H&E)-stained sections of xenograft tumors are shown. Low-magnification (Magnification: 4×, scale bar: 200 μm) and high-magnification (Magnification: 10×, scale bar: 50 μm) views demonstrate tumor cell morphology, with red arrowheads indicating regions of atypical mitotic figures and nuclear pleomorphism. (c) Representative image of tumor growth on day 3 after injection of A549 cells into the buccal mucosa. Tumor volume measured on day 3. (d)Tumors derived from RNF20-silenced cells were significantly larger, scale: mm. (*P < 0.05)

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