Table 1 Summary of the incident disease diagnoses within UK biobank cohort across two different follow up periods. Median follow-up time is based on the follow-up time from proteomic plasma measurement (baseline) until time to event (first diagnosis, death or censoring date, whichever occurs first).
15 years follow-up | 5 years follow up | ||||
|---|---|---|---|---|---|
Condition | Prevalent cases (N) | Cases (N) | Mean follow-up time (SD) | Cases (N) | Mean follow-up time (SD) |
Parkinson’s disease | 42 | 430 | 8.67 (4.25) | 102 | 2.81 (1.37) |
Atrial fibrillation | 619 | 3342 | 9.08 (4.24) | 707 | 2.82 (1.43) |
Asthma | 2225 | 2849 | 7.43 (4.26) | 951 | 2.64 (1.41) |
COPD | 381 | 2394 | 8.48 (4.22) | 596 | 2.80 (1.39) |
Dementia | 10 | 1096 | 10.50 (3.59) | 98 | 3.59 (1.23) |
Depression | 1034 | 2662 | 8.80 (4.05) | 554 | 2.87 (1.45) |
Type-2 Diabetes | 646 | 2332 | 9.06 (4.11) | 453 | 2.78 (1.44) |
Endometriosis | 298 | 184 | 6.28 (4.20) | 85 | 2.57 (1.50) |
Primary Malignancy – Pancreatic | 4 | 185 | 9.68 (4.01) | 34 | 3.35 (1.26) |
Heart failure | 247 | 2015 | 9.55 (4.29) | 388 | 2.76 (1.45) |
Motor neuron disease | 29 | 288 | 7.19 (3.19) | 81 | 3.31 (1.20) |
Multiple sclerosis | 226 | 167 | 7.25 (4.40) | 61 | 2.58 (1.51) |
Pulmonary embolism | 163 | 895 | 9.33 (4.18) | 162 | 2.89 (1.44) |
Primary pulmonary hypertension | 115 | 369 | 5.10 (3.13) | 221 | 3.06 (1.39) |
Primary Malignancy - Colorectal and anus | 155 | 776 | 8.86 (4.38) | 184 | 2.67 (1.40) |
Primary Malignancy - Brain, Other CNS and Intracranial | 12 | 125 | 8.25 (4.06) | 36 | 3.33 (1.28) |
Primary Malignancy – Breast | 659 | 1217 | 8.04 (4.39) | 359 | 2.71 (1.43) |
Primary Malignancy - Lung and trachea | 32 | 615 | 9.16 (4.10) | 137 | 3.35 (1.28) |
Primary Malignancy – Prostate | 131 | 1268 | 9.04 (4.36) | 287 | 2.73 (1.46) |
Rheumatoid Arthritis | 186 | 664 | 9.54 (3.66) | 80 | 3.20 (1.47) |
Schizophrenia | 99 | 119 | 8.38 (4.30) | 28 | 2.54 (1.72) |
Lupus erythematosus (local and systemic) | 267 | 259 | 5.84 (3.48) | 116 | 2.68 (1.36) |
Psoriasis | 474 | 476 | 7.89 (4.68) | 156 | 2.38 (1.36) |
Primary Malignancy – Gynaecological | 126 | 332 | 7.98 (4.33) | 107 | 2.88 (1.41) |
Coronary heart disease | 1296 | 4070 | 8.24 (4.39) | 1137 | 2.63 (1.45) |
Ischaemic stroke | 93 | 921 | 9.79 (4.05) | 148 | 2.98 (1.40) |
End stage renal disease | 39 | 177 | 9.39 (4.00) | 28 | 2.88 (1.08) |
