Fig. 2

Age group survival differences in non-ICI and ICI eras. (A,B) Kaplan–Meier survival curves for younger (<65 years) vs. older (\(\ge\)65 years) in non-ICI (A) and ICI (B) eras. (C,D) Multivariate Cox models: in non-ICI (C), HR for \(\ge\)65 years is 1.05 (95% CI 0.97–1.13, p = 0.203); in ICI (D), HR is 1.37 (95% CI 1.24–1.51, p = 0.0001). (E,F) Cox survival curves in non-ICI (E) and ICI (F) eras for both age groups.