Fig. 6

(A) Representative µCT images (scale bars, 1 mm) and (B) ultra-high-resolution nanoCT images of the femoral metaphyses. The sites of trabecular separation are indicated by arrows. Microstructural analysis of distal femoral metaphysis in 3-month-old male and female ICR/Mlac-hydro and wild-type mice (WT) as determined by µCT, i.e., (C) trabecular bone volume normalized by tissue volume (BV/TV), (D) trabecular thickness (Tb.Th), (E) trabecular separation (Tb.Sp), (F) connectivity density (Conn.D), (G) degree of anisotropy. (H) Cortical thickness (Ct.Th) of femoral midshaft in 3-month-old male and female Mlac-hydro and WT determined by µCT. n = 7; **P < 0.01, ***P < 0.001 vs. age-matched WT control group.