Fig. 4 | Scientific Reports

Fig. 4

From: Development and validation of combined in vitro and in vivo assays for evaluating the efficacy of strontium-chelating compounds

Fig. 4

Absorption kinetics of strontium and Decorporol in mice: Strontium (Sr) was administered by oral gavage and detected using the ICP-AES technique. Strontium was absorbed into the circulation in a dose-dependent manner and was cleared within 24 h (A). Mice were administered 40 µmol/kg Decorporol via intraperitoneal injection 30 min after strontium gavage. Decorporol was detected in the blood of mice using the UPLC-MS technique. Strontium-bound Decorporol appeared in the circulation earlier than the calcium-bound form, confirming a higher affinity of Decorporol for strontium (B). (n = 3)

Back to article page