Table 1 Cell viability and antiviral activity of the Olive stem extract against HSV-1, coxsackievirus, and adenovirus with their cytotoxic concentration (CC50), half-maximal inhibitory concentration (IC50), and selectivity index (SI) under both treatment and neutralization effect.

From: Network pharmacology of olive stem extract, UPLC-HR-QTOF-MS profiling and antiviral activities aligned with UN sustainable development goals

 

Conc.

Anti-HSV-1

Anti-Coxsackievirus

Anti-Adenovirus

 

Treatment

Neutralization

Treatment

Neutralization

Treatment

Neutralization

olive stem extract

IC50 (µg/mL)

25.91 ± 1.02

66.49 ± 1.01

69.37 ± 2.64

35.77 ± 0.05

44.52 ± 2.06

29.54 ± 3.27

SI*

30.78

11.99

11.5

22.3

17.91

27

Acyclovir

IC50 (µg/mL)

3.01 ± 0.99

–

–

–

15.88 ± 1.63

–

SI*

24.05

–

–

–

4.55

–

  1. IC50 Half maximal inhibitory concentration; SI*= selectivity index (CC50/IC50), CC50 of acyclovir on Vero cell line = 72.381 µg/mL.
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