Fig. 3
From: The use of autologous platelet-rich plasma in embryo culture to obtain high-quality embryos
Comparison of usable embryo and high-grade embryo at each stage between previous and PRP-added groups in all study participants. (A) Total usable embryo rate showed higher numbers in PRP-added group (21.4% in PRP group vs. 15.8% in previous group, p = 0.001). (B–D) Ratio of usable embryo classified according to embryo stage. The PRP group showed a significantly lower rate at the cleavage stage and a significantly higher rate at the blastocyst stage (PRP group vs. previous group; 23.6% vs. 57.9% in cleavage stage, p = 0.001; 28.0% vs. 21.4% in morula stage, p = 0.142; 48.4% vs. 20.8% in blastocysts stage, p = 0.001). (E–G) Ratio of high-grade embryo classified according to embryo stage. While there was no significant difference at the cleavage stage, the ratio of high-grade embryo was lower in the PRP group, similar to the changes observed in total usable cleavages (PRP group vs. previous group; 6.7% vs. 11.9% in cleavage stage, p = 0.073). At the morula and blastocyst stages, the ratio of high-grade embryo was significantly higher in the PRP group (PRP group vs. previous group; 15.6% vs. 7.5% in morula stage, p = 0.018; 44.0% vs. 17.6% in blastocysts stage, p = 0.001). (High-grade criteria: Cleavage stage; ≥ 8 cells G2, Morula stage; ≥ fully compacted, Blastocyst stage; ≥ early-stage graded BC/CB).
