Fig. 5 | Scientific Reports

Fig. 5

From: Potential role of TNFRSF12A in linking glioblastoma and alzheimer’s disease via shared tumour suppressor pathways

Fig. 5

Inverse regulation of TSGs in bulk cohort analysis between AD and GBM. (a) DEGs between AD and healthy control (HC) in the bulk cohort (GSE122063), with the distribution of TSGs denoted by gray circles. (b) DEGs between GBM and HC in the TCGA bulk cohort (TCGA-GBM), with the distribution of TSGs denoted by gray circles. (c) The expression pattern of TSGs in both AD and GBM (bulk cohorts). (d) Bar plots depicting the enrichment analysis of TSGs in AD through GO and KEGG pathways according to the fold change, with measured significance by -log10(adj.P.Val). (e) Bar plots depicting the enrichment analysis of TSGs in GBM through GO and KEGG pathways according to the fold change. (f, g) The Venn diagram illustrates DEGs that exhibit inverse expression trends in AD and GBM comparing to their respective HC. (h, i) Confirming the scRNA-seq expression profiles of selected genes (such as EGR2, GLIPR1, PEG3) that display reverse expression trends in AD and GBM.

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