Fig. 10 | Scientific Reports

Fig. 10

From: Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents

Fig. 10

2D interaction diagram of Quinazolinone Derivative 5 with (a) topoisomerase II (PDB: 5ZAD) compared to (b) doxorubicin, a known topoisomerase II inhibitor. The diagram illustrates key binding interactions, including hydrogen bonds, hydrophobic contacts, and π-π stacking, highlighting the binding mode similarities and differences between Quinazolinone Derivative 5 and the reference drug doxorubicin. These interactions suggest the potential of Quinazolinone Derivative 5 as a topoisomerase II inhibitor.

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