Fig. 11 | Scientific Reports

Fig. 11

From: Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents

Fig. 11

2D interaction diagrams of Quinazolinone Derivative 5 with key molecular targets, compared to reference inhibitors. (a) Interaction of Quinazolinone Derivative 5 with VEGFR2 (PDB: 3WZE), showing binding interactions relative to (b) sorafenib, a known VEGFR2 inhibitor. (c) Interaction of Quinazolinone Derivative 5 with c-MET (PDB: 3U6I), compared to (d) crizotinib, a well-established c-MET inhibitor. The diagrams highlight key molecular interactions, including hydrogen bonds, hydrophobic interactions, and π-π stacking, providing insights into the binding mode and potential inhibitory activity of Quinazolinone Derivative 5 against VEGFR2 and c-MET.

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