Table 4 Key ADME parameters of Quinazolinone derivatives.

Molecule	Molecular Weight (g/mol)	TPSA (Ã…Â²)	Log P (iLOGP)	GI absorption	BBB permeability	P-gp substrate	Bioavailability score
2	367.4	60.17	3.3	High	Yes	No	0.55
3	399.44	101.29	2.23	High	No	No	0.55
4	364.42	48.51	3.31	High	Yes	Yes	0.55
5	364.42	48.51	3.31	High	Yes	Yes	0.55
6	364.4	58.89	3.13	High	No	Yes	0.55
7	381.43	77.98	3.11	High	No	No	0.55
8	423.46	81.06	3.15	High	No	No	0.55
9	511.53	89.34	3.45	High	No	No	0.17
10	423.46	78.51	2.93	High	Yes	No	0.55
11	516.61	108.11	3.88	Low	No	No	0.17
12	442.47	130.39	2.2	High	No	No	0.55
13	424.45	107.08	2.89	High	No	No	0.55
14	611.69	82.14	4.94	Low	No	No	0.17
15	653.73	91.37	4.94	Low	No	No	0.17

This table summarizes selected Pharmacokinetic properties predicted using swissadme. Parameters include molecular weight (MW), topological Polar surface area (TPSA), lipophilicity (Log P via iLOGP), Gastrointestinal (GI) absorption, blood-brain barrier (BBB) permeability, P-glycoprotein (P-gp) substrate prediction, and estimated oral bioavailability score.

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