Fig. 6 | Scientific Reports

Fig. 6

From: The key regulation of LncRNA MALAT during reprogramming of primary mouse hepatocytes into insulin producing cells

Fig. 6

Over-expression of lncRNA MALAT1’s influence on associated gene expression during the process of differentiation induction is examined. (A) qPCR measures the alteration in lncRNA MALAT1 expression following over-expression plasmid transfection. (B, C) qPCR assesses miR-124-3p, PI3K, and pancreatic development-related gene expression in dedifferentiated cells. (D, E) In vitro glucose (5.5mM and 25mM, IPCs stage, per 106 cells) stimulation experiments are conducted. (*P < 0.05, **P < 0.01, ***P < 0.001, ns means no statistically significant differences between the two groups).

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