Fig. 1

Algorithm establishment of polygenic risk scores in predicting rheumatoid arthritis (RA) development. LDpred2 (blue), PLINK (purple), and PRSice-2 (yellow) methods were used to estimate the RA susceptibility. Area under the curve (AUC) analyses for assessment of the accuracy of the model in predicting RA development in the training set (A), the testing set (B), and in all patients (C).