Fig. 5
Evaluation of the Tumor-Suppressing Ability of NDP@MnO2 Hydrogel with 808 nm Laser in Orthotopic Pancreatic Tumor-Bearing Rabbits. (a) Schematic diagram of the experimental design for orthotopic pancreatic cancer-bearing rabbits. (b) Digital images illustrating the process of using NDP@MnO2 hydrogel combined with 808 nm laser treatment after in situ resection of pancreatic tumors in rabbits. (c) Intraoperative photographs obtained via laparotomy 16 days post-treatment, showing the presence or absence of recurrent pancreatic cancer (PC). CT coronal sections were analyzed to evaluate tumor recurrence, and specimens were collected for further examination. White circles indicate recurrent tumors. (d) Ex vivo histological analysis of tumor sections stained with H&E and TUNEL staining (n = 3). H&E Scale bar: 50 μm; TUNEL Scale bar, 200 μm. (e) Quantitative statistics of AOD of TUNEL fluorescence in each group were conducted using the ImageJ software. Data are expressed as mean ± S.D. (n = 3). *P<0.05, **P<0.01, ***P<0.001 by Student’s t-test.
