Table 2 Cox regression models on outcome by CD15+, MPO+, CD15+/MPO+ immune cells, or CD15+ tumor cells (CD15+ TC) in primary breast tumors.

From: Myeloperoxidase expressing tumor associated neutrophils are associated with worse prognosis in metastatic breast cancer patients

Variable

Progression-free survival

Hazard ratio (95% CI)

Overall survival

Hazard ratio (95% CI)

Unadjusted

P-value

Adjusted

P-value

Unadjusted

P-value

Adjusted

P-value

Primary tumor

CD15+ few cells

CD15+ many cells

MPO+ few cells

MPO+ many cells

CD15+MPO+ few cells

CD15+MPO+ many cells

CD15+ TC – few cells

CD15+ TC – many cells

1.04 (0.67–1.63)

0.67 (0.33–1.36)

1.26 (0.83–1.90)

2.52 (1.33–4.78)

1.20 (0.81–1.77)

3.77 (1.65–8.60)

0.72 (0.31–1.68)

0.93 (0.51–1.70)

0.85

0.27

0.27

0.004

0.37

0.002

0.45

0.80

0.88 (0.51–1.55)

0.58 (0.22–1.50)

0.71 (0.39–1.3)

1.65 (0.74–3.69)

0.94 (0.55–1.60)

3.04 (1.13–8.19)

0.92 (0.34–2.52)

0.56 (0.26–1.21)

0.67

0.26

0.27

0.22

0.81

0.028

0.87

0.14

1.28 (0.81-2.00)

0.87 (0.43–1.76)

1.17 (0.76–1.79)

2.35 (1.23–4.49)

0.96 (0.64–1.45)

4.12 (1.78–9.57)

0.99 (0.43–2.28)

0.49 (0.24–1.02)

0.288

0.694

0.480

0.010

0.856

< 0.001

0.989

0.057

1.15 (0.66-2.00)

0.72 (0.26–1.98)

0.64 (0.36–1.14)

1.33 (0.61–2.88)

0.75 (0.43–1.31)

2.04 (0.75–5.54)

1.00 (0.36–2.85)

0.30 (0.12–0.74)

0.61

0.53

0.13

0.48

0.31

0.16

0.99

0.009

  1. Adjusted for age at metastatic breast cancer diagnosis, ECOG performance status (0, 1, 2), NHG (III versus I-II), Subtype (ER+/HER2-, HER2+, TNBC), MFI (0, > 0–3, > 3), number of metastatic sites (< 3/>=3), site of metastasis (visceral/non-visceral).