Table 1 MIC, MBC and MBEC determinations of different antibiotics and combinations.

From: Bithionol is ineffective in a mouse model of S. aureus implant-associated osteomyelitis despite potent in vitro activity

Antibiotic

MIC (mg/L)

MBC (mg/L)

MBEC (mg/L)

Bithionol (BIT)

2

4

8

Moxifloxacin (MOX)

0.125

0.25

0.25

Daptomycin (DAP)

1

2

4

BIT + DAP (4 mg/L)

-

-

32

BIT + MOX (1 mg/L)

-

-

4

  1. Brackets after antibiotics indicate the fixed concentration used for MBEC combination therapy experiments with bithionol. DAP = daptomycin, MOX = moxifloxacin. For MBEC experiments: n = 4.
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