Fig. 5 | Scientific Reports

Fig. 5

From: Local microglial activation induced and labeled in the retina in a novel subretinal hemorrhage mouse model

Fig. 5

Change in the number of activated microglia due to SRH. (A) Typical morphological changes from our dataset, ranging from non-activated (top row), ramified (middle row) to activated, amoeboid (bottom) scale bar: 10 μm. (B) The SRH (BZ1) site showed a pronounced increase in the activated microglia count in comparison to all other SRH zones, including neighboring (BZ2), off-site (BZ3), and contralateral retinal (Z4). PBS injected and neighboring retinal zones (PZ1-2) showed a significant, but mild increase in activated numbers versus Z4. (C) After 24 h, we detected a small decrease in the total number of microglia in BZ1-4. Interestingly, a small, non-significant decrease was detectable in the PBS injected eye (PZ1-3) vs. the contralateral eye (Z4) in the total number of microglia. Kruskal-Wallis, Dunn’s post hoc **p < 0.01 o = outlier x = mean. Original dataset available in the Supplement.

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