Fig. 6 | Scientific Reports

Fig. 6

From: A single acute alcohol intoxication before fracture insult causes long-term elevated systemic RANKL and OPG levels in young adult mice

Fig. 6

Systemically analyses of bone turnover markers via ELISA. (a) Aged drunken mice with an isolated fracture showed a higher concentration of β-CTx in the plasma than the sober counterpart. (b) The RANKL value was increased in both older Fx and THFx mice after alcohol intoxication in contrast to the NaCl groups. (c) OPG only rose in drunken Fx animals in comparison to the not drunken ones. (d) For the RANKL/OPG ratio, young mice with isolated fracture with and without severe bleeding had higher values than the sober animals. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. indicated group; # p < 0.05 vs. respective Sham group. n = 5 per group.

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