Scientific Reports

Table 1 Significant over- and underrepresented miRNAs affected by breed and sex in feline WB. Results show significant miRNAs following evaluation with simple single group models and with different prefiltering steps of the data.

From: Profiling of the microRNA transcriptome in feline whole blood

Breed (n = 12)
10 row sum counts			5 row mean counts
miRNA	log₂ FC	padj	miRNA	log₂ FC	padj
miR-125b-5p	4.0^†	0.039	miR-125b-5p	4.0^†	0.039
miR-375-3p	− 1.5^†	0.039	miR-375-3p	− 1.5^†	0.039
A2_1436	− 4.3	0.061	let-7c-5p	1.1^†*	0.091
miR-144-5p	1.3^†*	0.091	miR-144-5p	1.3^†*	0.091
miR-151a-3p	− 0.7	0.091	miR-151a-3p	− 0.7	0.091
miR-330-5p	− 1.0	0.091	miR-3059-5p	− 1.8	0.091
miR-331-3p	− 0.6	0.091	miR-330-5p	− 1.0	0.091
miR-3613-5p	1.9^†*	0.091	miR-331-3p	− 0.6	0.091
miR-99a-5p	4.5^‡	0.091	miR-3613-5p	1.9^†*	0.091
let-7c-5p	1.1^†*	0.099	miR-99a-5p	4.5^‡	0.091
miR-3059-5p	− 1.8	0.099	miR-98-5p	1.0^†*	0.093
miR-98-5p	1.0^†*	0.099	miR-26b-5p	0.6^†*	0.100
			miR-326	− 0.8	0.100

Sex in NFO (n = 6)
10 row sum counts			5 row mean counts
miRNA	log₂ FC	padj	miRNA	log₂ FC	padj
miR-150-5p	1.5^‡	0.003	miR-150-5p	1.5^‡	0.004
miR-146a-5p	1.4	0.015	miR-146a-5p	1.4	0.014

A Benjamini-Hochberg (BH) adjusted p-value (padj) of ≤ 0.1 was considered significant. Trends validated in additional WB-samples for similar group-comparison are marked with ^†. Similar trends validated but for other group-comparison (both breeds included for sex-comparison, and only HCM-affected cats compared for breed), are marked with ^‡. Trends of validation results that are significant are marked with *. FC = fold change; NFO = Norwegian Forest cat.

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