Table 6 Inflammatory marker mediating the association between sleep disturbance and hypertension. ACME indicates average causal mediation effects (e.g., indirect effects), ADE, and average direct effects. Analyses were adjusted for age, race/ethnicity, education level, marital status, BMI, smoking status, alcohol status, and comorbid conditions. Sex was adjusted in the analyses of the total population, but not in subgroups of male or female.
From: Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES
SII | ACME | ADE | ||||||
|---|---|---|---|---|---|---|---|---|
Estimate | 95% CI lower | 95% CI upper | P-value | Estimate | 95% CI lower | 95% CI upper | P-value | |
Unadjusted Analyses | ||||||||
Total | 0.0015 | 0.0008 | 0.0023 | < 0.0001 | 0.1813 | 0.1667 | 0.1952 | < 0.0001 |
Male | 0.0041 | 0.0025 | 0.0062 | < 0.0001 | 0.1860 | 0.1637 | 0.2071 | < 0.0001 |
Female | 0.0001 | −0.0002 | 0.0005 | 0.71 | 0.1761 | 0.1566 | 0.1949 | < 0.0001 |
Adjusted Analyses | ||||||||
Total | 0.0004 | 0.0000 | 0.0009 | 0.022 | 0.0854 | 0.0716 | 0.0989 | < 0.0001 |
Male | 0.0013 | 0.0004 | 0.0024 | 0.002 | 0.0917 | 0.0715 | 0.1152 | < 0.0001 |
Female | 0.0001 | −0.0002 | 0.0004 | 0.582 | 0.0796 | 0.0610 | 0.09 | < 0.0001 |
