Table 3 Univariate and multivariate analysis of prognostic parameters and treatment approach.

From: Metastasis directed radiotherapy versus standard of care for PSMA-PET diagnosed oligometastatic/oligoprogressive castration resistant prostate cancer

Parameter

Univariate cox regression analysis

multivariate cox regression analysis

HR

p

HR

p

Progression free survival

Radiotherapy

0.62 (0.34–1.12)

0.114

0.36 (0.13–0.94)

0.048

Age

1.03 (0.98–1.08)

0.229

1.01 (0.93–1.11)

0.73

Time interval initial diagnosis to PSMA-PET

1.00 (0.96–1.01)

0.995

1.00 (0.99–1.02)

0.37

Initial PSA

1.002 (1.00–1.01)

0.088

1.00 (0.99–1.01)

0.06

Gleason score

0.96 (0.67–1.37)

0.825

0.78 (0.39–1.51)

0.46

Initial tumor stage

1.05 (0.74–1.49)

0.791

1.16 (0.67–2.00)

0.587

Charlson comorbidity index

1.06 (0.54–2.05)

0.875

1.28 (0.53–3.09)

0.586

Duration of ADT until PSMA-PET

1.00 (0.99–1.01)

0.744

0.99 (0.98–1.01)

0.220

PSA at PSMA-PET

1.00 (0.95–1.04)

0.864

1.06 (0.93–1.22)

0.387

PSA doubling time

1.02 (0.96–1.07)

0.586

1.00 (0.93–1.08)

0.958

Subsequent ARPI use

1.23 (0.59–2.57)

0.584

2.45 (0.75–7.99)

0.137

Subsequent cytostatica

1.02 (0.98–1.06)

0.408

1.05 (0.98–1.11)

0.143

Overall survival

Radiotherapy

0.41 (0.20–0.85)

0.016

0.14 (0.03–0.57)

0.006

Age

1.05 (0.99–1.11)

0.087

1.02 (0.92–1.13)

0.697

Time interval initial diagnosis to PSMA-PET

0.99 (0.99–1.002)

0.118

0.99 (0.98–1.01)

0.837

Initial PSA

1.00 (0.99–1.01)

0.127

1.00 (0.99–1.01)

0.153

Gleason score

2.05 (1.25–3.36)

0.005

2.05 (0.76–5.52)

0.154

Initial tumor stage

1.01 (0.68–1.50)

0.961

0.36 (0.13–1.01)

0.052

Charlson comorbidity index

2.05 (0.96–4.41)

0.065

0.73 (0.18–3.01)

0.671

Duration of ADT until PSMA-PET

0.99 (0.98–1.00)

0.040

0.99 (0.97–1.003)

0.103

PSA at PSMA-PET

0.99 (0.93–1.06)

0.763

0.77 (0.58–1.03)

0.077

PSA doubling time

0.97 (0.89–1.04)

0.376

1.03 (0.91–1.15)

0.659

Subsequent ARPI use

0.56 (0.25–1.29)

0.176

0.46 (0.10–2.11)

0.318

Subsequent cytostatica

0.96 (0.82–1.14)

0.660

0.99 (0.83–1.20)

0.972

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