Fig. 7
From: Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway
FoxO1 inhibition aggravated hepatic IRI. (A) Representative images of HE staining (100x) and the Suzuki’s score. (B) Representative images of TUNEL staining (100x) and cell apoptosis rate. (C) Serum ALT levels and AST levels (n = 5). (D–G) Serum GLUC, FFA, TRIG and lactate levels (n = 5). (H) Liver GSH/GSSG ratio (n = 5). (I) Representative blots of p-FoxO1, FoxO1, PCK1, CPT1a and PPARα and their quantification results. (J) Schematic illutration on the proposed mechanism of FoxO1/PPARα-mediated energy metabolism contributes to the alleviation of hepatic IRI in MH. Data are expressed as mean ± SD; *P < 0.05, **P < 0.01.
