Fig. 2 | Scientific Reports

Fig. 2

From: Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

Fig. 2

Preventive effects of intravitreal injection of felodipine against impaired optic nerve head (ONH) blood flow induced by endothelin-1 (ET-1) in the rabbit eyes. Under a conscious condition, each animal received intravitreal injection of vehicle or 780 nmol/eye felodipine prior to ET-1 (5 pmol/eye) intravitreal injection. ONH tissue blood flow was measured by laser speckle flowgraphy before and 72 h after ET-1 injection. (a) Effect of ET-1 alone on tissue blood flow (MBR-T) measured before and 72 h after concurrent injection of ET-1 and vehicle. †P < 0.05 (Paired t-test) compared with the baseline (time 0). (b) Effect of vehicle or felodipine on ET-1-induced ONH blood flow impairment. ONH blood flow measured at 72 h after ET-1 injection is expressed as a percentage of the pre-treatment value (baseline) in each group. *P < 0.05 (Student’s t-test) compared with vehicle. Each value represents the mean ± SEM of 7 to 8 eyes.

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