Fig. 2 | Scientific Reports

Fig. 2

From: Identification of a key smooth muscle cell subset driving ischemic cardiomyopathy progression through single-cell RNA sequencing

Fig. 2

Visualization of smooth muscle cell subpopulations in cardiomyopathy (A) The spatial distribution of all cells in the selected cardiomyopathy samples (left) and their distribution across different groups (right) were depicted in a 3D UMAP plot. (B) The UMAP plot illustrated the specific distribution of 24 samples selected from GSE145154. (C) Smooth muscle cells were categorized into nine subpopulations based on differential expression of marker genes. The UMAP plot displayed their distributions and provided information about the proportions of different groups and cell cycles within each subpopulation. (D) Average expression levels of differentially expressed genes in the nine smooth muscle cell subpopulations were presented in a bubble plot. (E) Pie charts directly showed the proportions of cell cycles and different groups within each subpopulation on the UMAP plot. (F) Box plots illustrated the nFeature_RNA and nCount_RNA of the nine smooth muscle cell subpopulations. (G) Volcano plots depicted the top 5 upregulated and top 5 downregulated genes in the nine smooth muscle cell subpopulations. (H) Highly expressed differential genes in the nine smooth muscle cell subpopulations were subjected to GO-BP enrichment analysis.

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