Table 6 Comparison of model performance across dosing protocols on Patient 21. Each row shows the BIS drop time and minimum BIS for a specific model and regimen.
From: Modeling drug retention as memory effects in obese patients using fractional and augmented models
Protocol / Model | \(t_{\text {BIS}<50}\) (min) | BIS nadir | Total drug (mg) |
|---|---|---|---|
One bolus | |||
  Classical | 2.1 | 50.35 | 100 |
  Augmented | 2.1 | 50.35 | 100 |
  Fractional (\(\alpha =0.5\)) | 2 | 49.7 | 100 |
  Fractional (\(\alpha =0.1\)) | 1.9 | 48.9 | 100 |
Repeated boluses | |||
  Classical | 6.63 | 43.2 | 192 |
  Augmented | 6.63 | 43.2 | 192 |
  Fractional (\(\alpha =0.5\)) | 6.56 | 41.67 | 192 |
  Fractional (\(\alpha =0.1\)) | 6.53 | 40.3 | 192 |
Infusion | |||
  Classical | 20.25 | 50.6 | 371.52 |
  Augmented | 20.25 | 50.6 | 371.52 |
  Fractional (\(\alpha =0.5\)) | 17 | 47.5 | 371.52 |
  Fractional (\(\alpha =0.1\)) | 15.9 | 46.3 | 371.52 |
