Fig. 1 | Scientific Reports

Fig. 1

From: Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase

Fig. 1

Depletion of hepatocyte FoxO1 aggravated MCD diet-induced MASH in vivo. (A and B) The knockout efficiency of FoxO1 in liver tissue was detected by qPCR and western blotting. (C) Representative images of H&E staining, Oil red staining, and Masson staining in WT and hepatocyte-specific FoxO1-KO mice. (D) Non-alcoholic fatty liver disease activity scores NAFLD activity scores were calculated. (E and F) Serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST). Statistical analysis was performed using the Student’s t-test. *, P < 0.05; ***, P < 0.001.(n = 5).

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