Table 1 Acute effects outcomes grouped by domain, presented as mean ± standard deviation, together with statistical significance and effect size (p < 0.05, p < 0.01, p < 0.001).

Outcome	Mean ± SD Psilocybin	Mean ± SD Control	p-value	RBC’s r
Eye-tracking metrics
N	77.00 ± 17.19	70.80 ± 10.32	0.454	0.23
ds	146.43 ± 27.42	170.19 ± 23.89	0.007**	−0.76
dt	0.39 ± 0.08	0.41 ± 0.05	0.454	−0.23
ds2	354.78 ± 41.93	381.87 ± 36.33	0.035*	−0.62
σ(ds)	129.93 ± 17.68	143.22 ± 19.32	0.018*	−0.68
σ(ds2)	210.56 ± 17.36	220.96 ± 15.35	0.035*	−0.62
σ(dt)	0.20 ± 0.03	0.20 ± 0.05	0.978	0.02
Shannon entropy (bw = 40)	5.83 ± 0.14	5.90 ± 0.13	0.035*	−0.62
Shannon entropy (bw = 60)	5.12 ± 0.15	5.19 ± 0.13	0.041*	−0.6
Shannon entropy (bw = 80)	4.59 ± 0.15	4.67 ± 0.12	0.022*	−0.67
Shannon entropy (bw = 100)	4.18 ± 0.15	4.25 ± 0.12	0.022*	−0.67
Intensity effects ratings
VAS 1 total	17.56 ± 8.47	9.91 ± 3.80	0.002 **	0.8
VAS 2 total	21.83 ± 7.79	11.87 ± 5.19	0.0001***	0.84
VAS 3 total	20.00 ± 7.56	9.35 ± 2.76	8e-5 ***	0.96
VAS 4 total	14.95 ± 8.00	7.91 ± 1.35	0.001 **	0.87
Trial-wise ratings
Emotional valence	0.52 ± 0.35	0.41 ± 0.35	0.232	0.3
Beauty rating	1.15 ± 0.6	1.13 ± 0.51	0.708	0.1
AEQ factors ratings				Cohen’ s d
Emotional	18.38 ± 5.55	15.26 ± 5.79	0.004 (**)	0.55
Cultural	19.48 ± 6.12	20.74 ± 6.35	0.341	0.2
Perceptual	16.14 ± 3.53	16.78 ± 4.08	0.494	0.17
Understanding	17.38 ± 5.36	18.04 ± 4.81	0.658	0.13
Flow conditions	11.19 ± 4.38	10.22 ± 2.80	0.287	0.27
Flow experience	19.81 ± 4.37	16.78 ± 4.65	0.015 (*)	0.67

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