Fig. 1 | Scientific Reports

Fig. 1

From: The inner nuclear membrane protein, Banf1, has an essential role in triple negative breast cancer cell proliferation and survival

Fig. 1

Banf1 expression is elevated in TNBC tumours. (a – b) Box plots comparing Banf1 gene expression levels in normal breast tissue to tumorigenic tissue from breast cancer samples within The Cancer Genome Atlas (TCGA) RNAseq dataset. P values were calculated using the unpaired Mann-Whitney U test, compared to normal tissue samples. Samples number for each group is shown on the x-axis. (a) Comparison of non-tumorigenic breast tissue to breast cancer stages I-IV (n = 1092 patients) (b) Comparison of non-tumorigenic breast tissue and all, normal-like, luminal A, luminal B, HER2 and basal breast carcinomas. (n = 1092). (c) Kaplan-Meier values for Banf1 mRNA expression in breast cancer patients showed high expression of Banf1 significantly decreases the probability of relapse-free survival (RFS) in breast cancer patients (n = 3951 patients, ****, p < 0.0001). Banf1 expression was divided into high or low expression based on the median expression within the dataset. Statistical significance was determined using the log-rank test in Graph Pad Prism 8. (d) Kaplan-Meier values for Banf1 mRNA expression in breast cancer patients showed high expression of Banf1 did not significantly decreases the probability of overall survival (OS) in breast cancer patients (ns, p > 0.78). Raw data was obtained for overall survival (n = 1402 patients) from KM plotter using the JetSet Probe Set.

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