Fig. 4 | Scientific Reports

Fig. 4

From: The inner nuclear membrane protein, Banf1, has an essential role in triple negative breast cancer cell proliferation and survival

Fig. 4The alternative text for this image may have been generated using AI.

siRNA mediated Banf1 depletion inhibits TNBC cellular proliferation and induces cell death. (a-e). Representative proliferation curves from 72 h post transfection with Control and Banf1 siRNAs using the Incucyte S3 live cell imaging system in MCF10A and TNBC cells. (a) MCF10A (b) BT549 (c) Hs578T (d) MDA-MB231 and (e) MDA-MB-468 (f – j) Relative area under the proliferation curve for (a – e) from independent experiments. (k-o) Graphs represent percent of viable cells post transfection with Control, Banf1 #1 and Banf1 #2 siRNA (k) MCF10A (l) BT549 (m) Hs578T (n) MDA-MB-231 and (o) MDA-MB-468. Values are normalised back to Control siRNA for respective cell lines. All graphed values represent results from individual repeats and error bars denote S.D. Statistical significance was calculated using unpaired t-test: ****, < p 0.0001, ***, < p 0.0002, **, p < 0.0021, *, p < 0.0332 (n=3 for all experiments).

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