Fig. 1
Characterization of the ciprofloxacin-loaded mucosomes. (a) Transmission electron microscopy images representing the size and the morphology of both empty and ciprofloxacin-loaded mucosomes; images acquired at 100 k× magnification (scale bar = 200 nm). The red dashed circumference was added subsequently to better highlight the perimeter of mucosomes. (b) Release kinetics of ciprofloxacin from mucosomes into PBS at pH = 7.4. c) Photograph taken 3 h after suspending free ciprofloxacin (1.0 mg/mL) in different solvents (dH₂O with or without 5% or 10% DMSO), showing noticeable Active Pharmaceutical Ingredient sedimentation in the free ciprofloxacin samples, in contrast to the absence of deposition in cipro-loaded NP suspensions.
