Table 1 Physico-chemical characterisation of hydrated loaded and unloaded mucosomes.

From: Mucosomes as next-generation drug carriers for treating mucus-resident bacterial infections and biofilms

 

Radius of gyration, R̅g, w(in-line SLS, nm)a

Hydrodynamic radius, R̅h, w (in-line DLS, nm)b

Shape factor R̅g, w/R̅h, wc

Hydrodynamic radius, R̅h, n (batch NTA, nm)d

Concentration (batch NTA, 1010 particles /mL)e

Unloaded

115 ± 5

130 ± 15

0.9 ± 0.1

85 ± 1

4.3 ± 0.06

Ciprofloxacin

90 ± 6

95 ± 3

0.9 ± 0.2

95 ± 2

2.9 ± 0.3

  1. aWeight-average radius of gyration obtained by using SLS and refractive index on-line detectors during AF4 analysis. n = 3 measurements of the same sample.
  2. bWeight-average hydrodynamic radius obtained by using DLS as an on-line detector during AF4 analysis. n = 3 measurements of the same sample.
  3. cShape factor obtained as the ratio of the values of radius of gyration and hydrodynamic radius see a and b).
  4. dNumber-average hydrodynamic radius obtained by using batch NTA n = 3 measurements of the same sample.
  5. eNumber concentration of particles (number of particles per volume unit), n = 3 measurements on the same sample.
Back to article page