Fig. 9
From: Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 pathway activation
TBF regulated the AMPK pathway and the changes in its downstream mitochondrial dynamics of HG-induced SCs. (A) The protein levels of p-AMPK, AMPK, PGC-1α in the SCS from different groups of NG group, HG group, TBF group (HG + 50, 100, 200 μg/mL TBF), AICAR group (HG + 0.5 mM AICAR). (B) The protein levels of p-DRP1, DRP1, FIS1, MFN1, MFN2 and OPA1 in the SCS from different groups of NG group, HG group, TBF group (HG + 50, 100, 200 μg/mL TBF), AICAR group (HG + 0.5 mM AICAR). Data are shown as mean ± standard deviation from three independent experiments. The outcomes were normalized to the values of the NG. β-tubulin images are reused. #p < 0.05; ##p < 0.01versus. NG. *p < 0.05; ** p < 0.01 versus. HG.
