Fig. 4
Tig1 and Prod1 overexpression increase model-predicted Proximalisation velocity and Diffusion coefficient. (A) Schematic representation of the Proximalisation model indicating its different terms and their effects on an ideal cellular density profile in a cartoonish limb. (B–D) (i) Spatial distributions of cell density for control (B), Tig1 (C) and Prod1 (D) along the proximal–distal (PD) axis at different days post electroporation (dpe). In grey, experimental data (Control, n = 3; Tig1, n = 4; Prod1, n = 4); in green, simulation using the Proximalisation model. The amputation plane is at the 0 μm position. The dashed vertical line indicates the mean position of the wrist, while the dotted vertical line indicates the mean position of the elbow (the shaded region represents the standard deviations). (ii) Posterior distributions of the parameters vp and D for the Proximalisation model.
