Fig. 4
From: Uncovering bifurcation behaviors of biochemical reaction systems from network topology
Macrophage polarization network for the wild type. By an arrow "\(\dashv\)" pointing from a complex to a reaction, we mean a negative regulation. The superscript \(+\) denotes the phosphorylated/activated form for each of the four complexes STAT1, STAT3, STAT6, and NF\(\kappa\)B, of which signalings are essential to the macrophage M1/M2 polarization. In this simplified network, the M1 polarization is primarily associated with the dominance of STAT1\({}^+\) and NF\(\kappa\)B\({}^+\), while the M2 polarization is associated with the dominance of STAT3\({}^+\) and STAT6\({}^+\).
