Fig. 2

Viability of A375 cells incubated with the same concentration of siRNAIGF1R/DOX/FBqS NPs and different concentrations of free folate (a); The distributions of FAM-siRNAIGF1R (green) and DOX (red) in A375 cells incubated with FAM-siRNAIGF1R/DOX/FBqS NPs, FAM-siRNAIGF1R/DOX/BqS NPs or free DOX at the same concentrations of FAM-siRNAIGF1R and DOX with or without excess free folate (b).