Fig. 2 | Scientific Reports

Fig. 2

From: Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae

Fig. 2

Dexamethasone-eluting implant reduces CX3CR1 + macrophage and cellular infiltration in the basal cochlear turn. CX3CR1+/eGFP Thy1+/eYFP mice were implanted with either a Standard cochlear implant (Standard CI) or dexamethasone-eluting Implant (Dex-CI). In a subset of the Standard CI group, Dexamethasone was injected into the round window niche (Dex-local). All implants were electrically stimulated, and mice were euthanized at 10, 28, 56, or 112 days (A–N). Maximum intensity z-projections of 3D confocal image stacks taken from 30-µm thick, midmodiolar sections showing the basal turn of the cochlea. Asterisks indicate the implant tract.

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