Fig. 4
Dexamethasone-eluting cochlear implants reduces α-SMA + fibrotic tissue response following cochlear implantation. Following cochlear implantation and electrical stimulation, mice were euthanized at desired endpoints (10, 28, 56, or 112 days). Harvested cochleae were sectioned at 30-µm thickness, immunolabeled with anti-α-SMA antibody, and imaged with a confocal microscope. Scala tympani of the base of the cochlea was traced. The volumes of the scala tympani and the volume of the α-SMA + fibrotic tissue was measured. Fibrosis was measured by dividing the α-SMA + fibrotic tissue by the volume of the scala tympani and expressed in percentage. Representative images of midmodiolar sections labeled with anti-α-SMA antibody (A–N).
