Table 1 Sensitivity analysis results of immune cells and keratoconus: heterogeneity test, horizontal Pleiotropy assessment, and the Steiger Test.

From: Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus

Exposure

Heterogeneity test

Pleio test

Steiger Test Pval

MRPRESSO Global Pval

Cochran’s Q

Cochran’s Q Pval

MR‒Egger intercept

MR‒Egger Intercept pval

IgD + CD38dim B cell %B cell

13.2389

0.4295

0.0967

0.0713

2.84E-70

0.448

BAFF-R on IgD + CD24 + B cell

11.7592

0.5475

0.0302

0.3876

<0.05

0.619

BAFF-R on IgD + B cell

24.6129

0.2166

0.0194

0.5191

<0.05

0.28

CD19 on IgD + CD38- unswitched memory B cell

17.0665

0.3813

−0.0288

0.5070

4.19E-105

0.385

CD19 on IgD + CD38dim B cell

13.0328

0.8369

−0.0077

0.7477

5.97E-110

0.846

CD19 on unswitched memory B cell

11.4820

0.7788

0.0071

0.7755

1.53E-94

0.822

CD20 on IgD- CD24- B cell

16.2171

0.8458

0.0161

0.4931

8.56E-127

0.882

CD25 on IgD + CD38- naive B cell

13.7173

0.9112

0.0292

0.2824

8.29E-155

0.936

CD25 on IgD + CD38 + B cell

10.6090

0.5627

0.0609

0.2108

9.55E-93

0.583

CD25 on IgD + B cell

29.3371

0.1694

0.0313

0.2778

2.21E-158

0.187

CD27 on CD20- B cell

6.2815

0.7911

0.0031

0.9332

1.54E-51

0.837

CD62L- Dendritic Cell %Dendritic Cell

18.5051

0.5542

−0.0136

0.5962

1.38E-278

0.685

CD86 on myeloid Dendritic Cell

13.4756

0.7038

−0.0123

0.7592

4.37E-90

0.733

CD86 on CD62L + myeloid Dendritic Cell

14.8990

0.6028

0.0047

0.8754

1.14E-92

0.635

CD3 on HLA DR + CD4 + T cell

24.6410

0.2630

0.0434

0.1620

4.88E-182

0.214

CD45 on HLA DR + Natural Killer

4.4955

0.6099

0.0087

0.8387

5.36E-32

0.613

SSC-A on CD14 + monocyte

20.8346

0.2878

0.0252

0.4407

6.31E-286

0.35

CD40 on CD14 + CD16 + monocyte

25.4509

0.1462

0.0306

0.5141

3.86E-305

0.195

CD14 on CD14 + CD16- monocyte

16.8072

0.2083

−0.0217

0.6412

4.92E-76

0.273

CD33- HLA DR + Absolute Count

18.2604

0.8661

0.0100

0.6884

1.13E-164

0.879

CD34 on Hematopoietic Stem Cell

8.2430

0.5099

0.0439

0.2238

6.31E-83

0.651

CD11b on CD14 + monocyte

16.1567

0.5816

0.0404

0.1512

5.15E-189

0.625

CD4 regulatory T cell %CD4 + T cell

9.3426

0.6734

0.0258

0.5482

5.39E-72

0.737

CD39 + resting CD4 regulatory T cell %CD4 regulatory T cell

28.7035

0.5332

0.0198

0.2595

<0.05

0.676

CD3 on activated & secreting CD4 regulatory T cell

23.9859

0.2937

0.0536

0.0596

2.00E-289

0.247

CD3 on CD28 + CD45RA- CD8 + T cell

13.0069

0.5260

0.0579

0.2240

2.76E-120

0.424

CD28 on CD28 + CD4-CD8- T cell

0.2123

0.8993

−0.0881

0.7315

5.44E-16

NA

CD127 on CD28 + CD45RA- CD8 + T cell

9.0341

0.7000

−0.0132

0.7283

2.49E-66

0.737

CD25 on CD39 + CD4 regulatory T cell

12.6752

0.4732

0.0071

0.8802

6.66E-74

0.496

CD4 on CD39 + resting CD4 regulatory T cell

9.4074

0.7415

0.0108

0.7679

1.11E-71

0.749

CD3 on Effector Memory CD8 + T cell

13.2135

0.7218

0.0057

0.8460

4.89E-128

0.626

CD45RA on Terminally Differentiated CD8 + T cell

15.6613

0.2072

−0.0115

0.8554

8.44E-66

0.266

Naive CD4 − CD8 − T cell Absolute Count

12.2343

0.5875

0.0302

0.4304

6.17E-74

0.681

  1. Cochran’s Q Cochran’s Q test, MR‒Egger intercept MR-Egger intercept test, IgD+ Immunoglobulin D-positive cells, HLA DR Human Leukocyte Antigen-DR isotype, BAFF-R B-cell activating factor receptor.
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