Table 2 Induction of DNA damage in the hepatic tissues of the negative control group and groups given orally TiO2 nanoparticles (TiO2-NPs) or/and acrylamide.

From: Acrylamide coadministration modulates hepatic ROS-mediated apoptotic DNA damage and inflammation induced by TiO2 nanoparticles in mice

Group

Treatment (dose mg/kg)

Tail length (px)

%DNA in tail

Tail moment

I

Negative control (0 mg/kg)

4.42 ± 0.87 a

16.70 ± 1.15 a

0.75 ± 0.18 a

II

Acrylamide (3 mg/kg)

11.41 ± 0.53 b

24.71 ± 0.98 b

2.94 ± 0.30 b

III

TiO2-NPs (5 mg/kg)

10.70 ± 2.23 b

25.64 ± 1.22 b

2.81 ± 0.57 b

IV

Acrylamide + TiO2-NPs

12.11 ± 0.15 b

28.30 ± 0.90 c

3.55 ± 0.10 c

One Way Analysis of Variance

F = 24.83

P < 0.001

F = 65.02

P < 0.001

F = 38.29 P < 0.001

  1. • Six mice were used for each group.
  2. • Results are expressed as mean ± SD.
  3. • Results were analyzed using one-way analysis of variance followed by Duncan’s test to test the similarity between the control and three treated groups.
  4. • According to Duncan’s test means with different letters indicates statistical significant difference between the compared groups in the same column at a significant level of p < 0.001.
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