Table 6 Co-dominant Model for CRC group (n = 200) tumor grade, low or high, association with demographic characteristics (age, BMI, sex, and family cancer history) and tumor clinical features (tumor site and vascular infiltration, IBD, and blood TMs) with LINC00511 SNPs rs1558535, rs17780195, and rs9906859 genotypes.

Age (year)

 < 0.001

 < 55

106/161 (66)

12/39 (31)

1.00

 > 55

55/161 (34)

27/39 (69)

2.55(0.9 — 7.17)

NS

BMI (Kg/m²)

NS

 < 25

36/161 (22)

6/39 (15)

1.00

 ≥ 25

125/161 (78)

33/39 (85)

1.41(0.46 — 4.3)

NS

Sex

0.002

Female

120/161 (75)

19/39 (49)

1.00

Male

41/161 (25)

20/39 (51)

3.04(1.18 — 7.81)

0.025

Family History

0.010

Negative

127/161 (79)

23/39 (59)

1.00

Positive

34/161 (21)

16/39 (41)

4.02(1.45 — 11.18)

0.009

Tumor site

NS

Colon

97/161 (60)

23/39 (59)

1.00

Rectal

64/161 (40)

16/39 (41)

0.6 (0.24 — 1.47)

NS

Vascular infiltration

NS

Absent

79/161 (49)

17/39 (44)

1.00

Present

82/161 (51)

22/39 (56)

0.94 (0.36 — 2.46)

NS

IBD History

 < 0.001

Negative

98/161 (61)

0/39 (0)

1.00

Positive

63/161 (39)

39/39 (100)

125.04(11.2 — 1392)

 < 0.001

CEA (ng/mL)

NS

 < 9

73/161 (45)

20/39 (51)

1.00

 > 9

88/161 (55)

19/39 (49)

0.90 (0.37 — 2.2)

NS

CA19-9 (U/mL)

0.025

 < 73

120/161 (75)

22/39 (56)

1.00

 > 73

41/161 (25)

17/39 (44)

2.13 (0.76 — 6)

NS

LINC00511 SNPs

rs1558535 A > T

NS

AA

33/161 (20)

6/39 (15)

1.00

AT

86/161 (53)

25/39 (64)

5.51 (0.12 — 2.15)

NS

TT

42/161 (26)

8/39 (21)

0.53 (0.08 — 3.65)

NS

rs17780195 A > G

NS

AA

93/161 (58)

23/39 (59)

1.00

AG

64/161 (40)

14/39 (36)

1.39 (0.53 — 3.68)

NS

GG

4/161 (2.5)

2/39 (5.1)

0.2 (0.02 — 2.24)

NS

rs9906859 T > C

NS

TT

24/161 (15)

2/39 (5.1)

1.00

CT

81/161 (50)

23/39 (59)

1.90 (0.23 — 15.58

NS

CC

56/161 (35)

14/39 (36)

7.43 (0.65 — 85.38)

NS